硅橡胶缓释管的筛选及体内埋植效果验证

Slow-Releasing Silastic Capsule Screening and In-vivo Effect Evaluation

目的筛选出一种制作简便、在体内有效工作的皮下埋植用硅橡胶缓释管，为研究药物的长期效应及毒副作用提供可靠的实验方法。方法以双氢睾酮作为试验用药物、雌性sD大鼠为动物模型，筛选出两种自制硅橡胶缓释管中性能（生物兼容性、体内稳定性）较优者，并进一步验证其在体内的释药效果。结果用医用粘合剂制作的硅橡胶缓释管封闭牢靠（体内稳定性好）、无明显的异物排斥反应（生物兼容性好）。并可在体内有效工作，明显优于用木质敷药棒制作的缓释管。结论用医用粘合剂制作的硅橡胶缓释管是一种适用于体内长期埋植的缓释管，可用于双氢睾酮等药物长期缓释给药和构建动物模型。

Objective To screen for a slow-releasing pare, can work effectively effects and side effects of in vivo, and serve as a reliable drugs. silastic capsule, which is easy to pre- experimental tool for studying long-term Methods The superior of two slow-releasing tubes was screened out, with dihydrotestosterone as a test drug and female SD rats as animal models. It would be more stable in vivo and have better biocompatibility. Its drug-releasing effect was further evaluated in vi- vo. Results The slow-releasing silastic capsule made of medical adhesive was tightly sealed （ good stability in vivo）, caused no obvious rejection reaction （better biocompatibility） and worked well in vivo in female SD rats. It was superior to the slow-releasing tube sealed with wood. Conclusion The slow-releasing silastic capsule made of medical adhesive is suitable for long-term implantation in vivo and can be used for long-term administration of DHT or other drugs and establishment of animal models.