蛋白质复合物组计算预测方法的研究与展望

Researchand Prospect of Computational Prediction Methods in Complexomes

当今系统生物学研究的重要课题之一就是蛋白质复合物组。对蛋白质复合物组中的蛋白质复合物及其相互作用进行全面、深入的研究，可以实现对蛋白复合物参与整个细胞生物进程的了解。近年来，大量从蛋白质组学数据中预测蛋白质复合物而得到复合物组网络表达的计算方法、计算模型已被开发出来，这类计算预测方法为生命活动的复杂规律研究提供了重要手段。现将蛋白质复合物组计算预测方法关于生物信息学的研究进步及在各研究领域的应用综述如下，并对其发展前景进行了展望。

One of the important hot topic in the field of systems biology is the complexomes. A comprehensive and in-depth research of protein complexes and its interactions of complexomes can a- chieve the understanding of protein complexes involved in the whole process of cell biology. In recent years, a large number of calculation methods and calculation models that predict protein complexes from proteomies data to obtain eomplexomes of network expression have been developed. The kind of computational prediction methods provide an important means for research of complex laws of life ac- tivities. This study reviewed the research progress of computational prediction methods of complex- omes in bioinformatics and its application to various research areas, and prospected the future of it.