152例青年结直肠癌患者的临床病理特点及预后分析

Prognosis and clinicopathological characteristics of young patients with colorectal cancer: a retrospective analysis of 152 cases

目的探讨青年结直肠癌患者的临床病理特点与预后的关系。方法回顾性分析有完整临床病理资料和随访资料的152例青年结直肠癌患者的临床特点、病理特征及生存情况。结果本组患者中位年龄为32岁,5年生存率为56%。单因素分析显示,病理类型、组织学分类、临床分期及根治性手术与预后有相关性(P<0.05)。应用COX回归风险比例模型分析显示,分期是影响生存的独立因素(P<0.001)。结论分期是影响青年结直肠癌预后的独立因素。

Objective To investigate the relationship between clinicopathological fetures and prognosis of young patients with colorectal cancer. Method The clinical characteristics,pathologic features,and survival of 152 young patients with colorectal cancer were retrospectively analyzed. Univariate and multivariate Cox proportional regression models were used for finding out the factors associated with survival. Result For all the patients,the median age was 32 years old and the 5-year survival rate was 56%. Univariate analysis showed that pathological type,histological classification,clinical stage,and radical operation are significantly associated with overall survival（ P〈0. 05）.Multivariate analysis shows that only staging is an independent prognostic factor（ P 0. 001）. Conclusion Staging is an independent prognostic factor in young colorectal cancer patients.