氩气刀联合冷冻、全身化疗治疗晚期恶性气道内狭窄的临床效果

The clinical observation of Argon, frozen and systemic chemotherapy for the treatment of advanced malignant airway stenosis

目的探讨氩气刀联合冷冻、全身化疗治疗晚期恶性气道内狭窄的临床效果。方法选择2010年3月至2014年5月本院接诊的60例晚期恶性气道狭窄患者为研究对象,按照入院时间先后顺序将其分为对照组和观察组,每组各30例。观察组患者采用氩气刀联合冷冻、全身化疗,对照组患者采用单纯全身化疗。比较两组患者治疗前后Karnofsky评分、气道直径、气促指数、疗效、阻塞性肺炎及肺复张发生情况。结果两组患者治疗前Karnofsky评分、气道直径、气促指数比较差异均无显著性(P>0.05),治疗后观察组患者Karnofsky评分、气道直径均高于对照组,气促指数低于对照组(P<0.001)。观察组患者治疗总有效率显著高于对照组(P<0.05)。治疗后观察组患者肺复张、阻塞性肺炎改善有效率均明显高于对照组(P<0.05)。结论氩气刀联合冷冻、全身化疗治疗晚期恶性气道内狭窄,可有效抑制恶性组织增生,缓解临床症状,效果良好,值得临床推广应用。

Objective To evaluate the clinical efficacy of Argon, frozen and systemic chemotherapy for the treatment of advanced malignant airway stenosis. Method 60 patients with advanced malignant airway stenosis from March 2010 to May 2014 in our hospital were researched. According to admission chronological order they were randomly divided into control group and observation group, 30 cases in each group. Observation group were treated with Argon, frozen and systemic chemotherapy. Control group were treated with conventional systemic chemotherapy. The two groups＇ Karnofsky score, airway diameter, dyspnea index, efficacy, obstructive pneumonia and lung reexpansion were compared. Result Two groups of patients before treatment Karnofsky score, airway diameter, dyspnea index had no statistically significant（P〈0.05）. After treatment, observation group patients with Karnofsky score and airway diameter were higher than control group, dyspnea index was lower than control group（P〈0.001）. Patients in observation group total effective rate was significantly higher than control group（P〈0.05）. The effective rate of pulmonary rehabilitation and obstructive pneumonia in observation group were significantly higher than control group（P〈0.05）. Conclusion The clinical efficacy of Argon, frozen and systemic chemotherapy for the treatment of advanced malignant airway stenosis is well, it＇s an effective way for inhibit malignant tissue hyperplasia, alleviate symptoms of symptoms, and it has clinical effect, can be widely used in clinical.