酮替芬联合沙美特罗替卡松治疗变应性咳嗽的效果观察

Effect observation of ketotifen combined with salmeterol/fluticasone propionate for treatment of allergic cough

目的观察酮替芬联合沙美特罗替卡松治疗变应性咳嗽的临床效果。方法选取2013年1月至2014年1月本院收治的80例变应性咳嗽患者为研究对象,采用随机数表法将其分为观察组和对照组,每组各40例。对照组患者口服复方甲氧那明,观察组患者口服酮替芬联合吸入沙美特罗替卡松。比较两组患者临床疗效,治疗前后日间、夜间咳嗽症状积分及嗜酸性粒细胞数和血清总免疫球蛋白E(Ig E)水平,治疗后不良反应发生情况。结果观察组药物起效时间为(4.35±1.57)天,对照组为(6.18±2.95)天,两组比较差异具有显著性(t=2.383,P<0.05)。观察组患者治疗总有效率显著高于对照组(P<0.05)。治疗前两组患者嗜酸性粒细胞数和血清总Ig E水平比较差异无显著性(P>0.05),治疗后两组患者上述指标水平均低于治疗前(P<0.05),观察组低于对照组(P<0.05)。治疗前两组患者日间、夜间咳嗽症状积分比较差异均无显著性(P>0.05),治疗后两组患者日间、夜间咳嗽症状积分均低于治疗前,观察组低于对照组(P<0.05)。观察组患者治疗后总不良反应发生率显著低于(P<0.05)。结论酮替芬联合沙美特罗替卡松治疗变应性咳嗽,临床效果显著,起效较快且不良反应少,值得临床推广应用。

Objective To observe the clinical effect of ketotifen combined with salmeterol/fluticasone propionate treated with allergic cough. Method Selected from January 2013 to January 2014 in our hospital 80 cases of allergic cough patients for the study, according to a random number table method were divided into observation group and control group, 40 cases in each group. Control group of patients treated with compound methoxyphenamine, observation group were treated with ketotifen combined with salmeterol/fluticasone propionate. Clinical curative effect, before and after the treatment day, nocturnal cough symptom scores and eosinophile cell number and total serum immunoglobulin protein（Ig E） level, adverse reactions were compared between the two groups. Result The onset time of valid cases in observation groupp was（4.35±1.57） days, control group was（6.18±2.95） days, the difference was significant（t = 2.383, P〈0.05）. Total effective rate in obselvation group was higher than control group（P〈0.05）. There were no significant differences in the number of eosinophils and serum total Ig E between the two groups before treatment（P〉0.05）. The levels of the above indicators in the two groups were lower than before treatment（P〈0.05）, but observation group was lower than control group（P〈0.05）. There were no significantly difference between the two groups in daytime and nighttime cough symptom score before treatment（P〉0.05）. After treatment, the two groups in daytime and nighttime cough symptom scores were lower than those before treatment, but observation group were lower than control group（P〈0.05）. The total adverse reaction of observation group was lower than control group（P〈0.05）. Conclusion Allergic cough treated with ketotifen combined with salmeterol/fluticasone propionate has significant clinical effect, rapid onset and fewer side effects, worthy of clinical application.