慢性肾衰竭患者甲状旁腺激素水平的变化及其意义

Changes and significance of parathyroid hormone levels in patients with chronic renal failure

目的:探讨血清甲状旁腺激素(PTH)在诊治慢性肾衰竭中的临床意义。方法:将40例慢性肾衰竭患者设为观察组,40例健康体检者设为对照组。测定两组研究对象的血清PTH、尿素氮(BUN)、血肌酐(Scr)、血钙、血磷水平,并进行相关性分析。结果:与对照组比较,观察组患者的血清PTH、尿素氮、血肌酐、血磷水平显著增加,血钙显著减少,差异有统计学意义(P<0.05)。观察组患者的血清PTH水平与尿素氮、肌酐、血磷水平呈正相关(r=0.55-0.68,P<0.05),而与血钙水平呈负相关(r=-0.38,P<0.05)。结论:血清PTH水平可以作为诊疗慢性肾衰竭的重要参考指标,对临床预防和早期处理钙磷代谢紊乱具有重要价值。

Objective:To investigate clinical significance of serum parathyroid hormone ( PTH) in diagnosis and treatment of chronic renal failure. Methods:40 cases of chronic renal failure patients ( observation group) and 40 cases of healthy subjects ( con-trol group) were selected. The serum PTH, BUN, Scr, calcium, and phosphorus levels were detected and correlatively analyzed. Re-sults:Compared with the control group, the serum PTH, BUN, Scr, phosphorus levels of chronic renal failure group were significantly increased, serum calcium level was decreased, and the differences between the two groups were statistically significant (P<0. 05). For the 40 cases of chronic renal failure patients, the serum PTH level was positively correlated with BUN, Scr, phosphorus levels ( r=0. 55-0. 68, P<0. 05), and negatively correlated with serum calcium level (r=-0. 38, P<0. 05). Conclusions: The PTH level in serum can be used as an important reference index of diagnosis and treatment of chronic renal failure, and has an important value for clinical prevention and early treatment of the disorders of calcium and phosphorus metabolism.