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Th17细胞与自身免疫性甲状腺疾病研究进展

Research Progress in the Role of Th17 in Autoimmune Thyroid Diseases
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摘要 辅助性T细胞17(Th17)是一种新型辅助T细胞亚群,主要表达白细胞介素17等效应因子,已证实其在自身免疫性疾病中发挥重要的调节作用。随着研究的深入,人们发现Th17细胞及其细胞因子亦参与了包括弥漫性毒性甲状腺肿、慢性淋巴细胞性甲状腺炎和甲状腺相关眼病在内的自身免疫性甲状腺疾病(AITD)的发病过程。该文就Th17细胞及其细胞因子在AITD发病中的作用研究进展予以综述。 The T helper cells 17(Th17) are a novel helper T cell subset,with interleukin 17(IL-17) as main expression ,have been proved to play an important regulatory role in the development of autoimmune dis-eases.Th17 cells may also contribute to the pathogenesis of autoimmune thyroid disorders(AITD) including diffuse toxic goiter disease,chronic lymphocytic thyroiditis,and thyroid-associated ophthalmopathy.Here is to make a review of the current knowledge regarding IL-17 and Th17 cells roles in the pathogenesis of AITD.
出处 《医学综述》 2015年第13期2361-2363,共3页 Medical Recapitulate
关键词 自身免疫性甲状腺疾病 TH17细胞 白细胞介素17 Autoimmune thyroid diseases Th17 ceils Interleukin-17
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参考文献21

  • 1Guo T,Huo Y,Zhu W,et al.Genetic association between IL-17Fgene polymorphisms and the pathogenesis of Graves'Disease in theHan Chinese population[J].Gene,2013,512(2):300-304.
  • 2Peng D,Xu B,Wang Y,et al.A high frequency of circulating th22and th17 cells in patients with new onset graves'disease[J].PLo SOne,2013,8(7):e68446.
  • 3Klatka M,Grywalska E,Partyka M,et al.Th17 and Treg cells inadolescents with Graves'disease.Impact of treatment with methimazoleon these cell subsets[J].Autoimmunity,2014,47(3):201-211.
  • 4Li X,Qi Y,Ma X,et al.Chemokine(C-C motif)ligand 20,a potential biomarker for Graves'disease,is regulated by osteopontin[J].PLo S One,2013,8(5):e64277.
  • 5Tsai KH,Tsai FJ,Lin HJ,et al.Thymic stromal lymphopoietin genepromoter polymorphisms and expression levels in Graves'diseaseand Graves'ophthalmopathy[J].BMC Med Genet,2012,13:116.
  • 6Zhou J,Bi M,Fan C,et al.Regulatory T cells but not T helper 17cells are modulated in an animal model of Graves'hyperthyroidism[J].Clin Exp Med,2012,12(1):39-46.
  • 7Lichiardopol C,Mota M.The thyroid and autoimmunity[J].Rom JIntern Med,2009,47(3):207-215.
  • 8Mao C,Wang S,Xiao Y,et al.Impairment of regulatory capacity ofCD4+CD25+regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves'disease[J].J Immunol,2011,186(8):4734-4743.
  • 9Ban Y,Tozaki T,Taniyama M,et al.Association studies of theIL-23R gene in autoimmune thyroid disease in the Japanese population[J].Autoimmunity,2009,42(2):126-130.
  • 10Horie I,Abiru N,Nagayama Y,et al.T helper type 17 immuneresponse plays an indispensable role for development of iodineinduced autoimmune thyroiditis in nonobese diabetic-H2h4 mice[J].Endocrinology,2009,150(11):5135-5142.

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