介入栓塞治疗非小细胞肺癌生存时间的影响因素分析及干预对策

Influencers on Embolization Treatment for Non-small Cell Lung Cancer and the Intervention Measures

目的 探讨介入栓塞治疗非小细胞肺癌远期疗效的影响因素,予以有效的干预,以提高临床效果。方法 选取2000年11月至2008年12月在首都医科大学附属北京安贞医院介入诊疗科治疗的170例非小细胞肺癌住院病例资料进行回顾性分析,所有患者均运用介入栓塞治疗,以5年生存期为准,分析影响生存时间的影响因素。结果 ≥5年的生存例数为39例,而在5年内死亡有131例。影响介入栓塞治疗非小细胞肺癌远期疗效的高危因素有病理分型（OR=7.254,95%CI1.321~28.044）、肿瘤淋巴结转移（OR=8.382,95%CI 1.464~27.832）、肿瘤低分化（OR=8.173,95%CI 1.503~26.042）。结论 肿瘤的病理分型、肿瘤淋巴结转移、肿瘤低分化等均是影响非小细胞肺癌远期疗效的重要因素,早期综合治疗是提高远期疗效的关键因素。

Objective To investigate the influential factors on long-term effect of embolization treatmentof non-small cell lung cancer,so as to give an effective intervention and improve the clinical results.Methods From Nov.2000 to Dec.2008 in Department of Interventional Diagnosis and Treatment,Beijing AnzhenHospital,Capital Medical University,170 cases of hospitalized non-small cell lung cancer were retrospectivelyanalyzed：all patients received embolization,using 5 year survival as standard to analyze the influential factorsfor the survival.Results There were 39 cases with a survival≥5 years,while there were 131 deaths in thefive years.High risk factors for long-term effects of interventional treatment for non-small cell lung cancerincluded pathological type（OR =7.254,95%CI 1.321-28.044）,lymph node metastasis（OR =8.382,95% CI 1.464-27.832）,poorly differentiated tumors （OR =8.173,95% CI 1.503-26.042）.Conclusion Pathologicaltype of tumor,lymph node metastasis,and poorly differentiated tumors aare important factors influencingthe long-term effect of the treatment,and early comprehensive treatment is the key factor to improve thelong-term efficacy.