长期小剂量阿奇霉素治疗稳定期支气管扩张的疗效研究

CLINICAL EFFICACY OF LONG-TERM LOW-DOES AZITHROMYCIN IN PATIENTS WITH BRONCHIECTASIS

目的观察长期口服小剂量阿奇霉素治疗稳定期支气管扩张症的临床疗效。方法将门诊及住院处于稳定期支气管扩张患者61例,随机分成二组,对照组给予祛痰治疗,观察组在祛痰基础上加用小剂量阿奇霉素,随访6个月,记录二组患者治疗期间急性发作次数、治疗前后圣乔治呼吸问卷(SGRQ)评分、第一秒用力呼气容积(FEV1)和痰液微生物学检查结果。结果二组治疗后观察组患者急性加重次数明显少于对照组,细菌阳性率降低,二组比较差异具有统计学意义(P<0.05);对照组患者治疗前后SGRQ、FEV1比较差异无明显统计学意义(P>0.05);观察组患者治疗后SGRQ、FEV1与治疗前比较均有改善,差异有统计学意义(P<0.05)。结论长期小剂量口服阿奇霉素可以提高患者肺功能,改善患者生活质量。

Objective To evaluate the efficacy of long-term and low dose Azithromycin in the treatment of bronchiectasis.Methods Sixty-one cases of bronchiectasis were randomly divided into treatment group and control group,these patients are in stable period.The control group was given the expectorant treatment,while the treatment group was given Azithromycin.Exacerbation frequency,St George＇s respiratory questionnaire,pulmonary function tests（FEV1）and sputum microbiology were recorded by 6 months follow-up.Results All patients completed the therapy for 6 months,and acute aggravating significantly was lower in the treatment group than the control group after treatment.Bacteria positive rate was also reduced,and the difference was statistically significant（p〈0.05）.The control group before and after treatment in patients with SGRQ,FEV1 comparison difference had no obvious statistical significance（P〉0.05）,but in treatment group after treatment in patients with SGRQ and FEV1 were improved compared with before treatment,the difference was statistically significant（p〈0.05）.Conclusion Long-term low-dose oral Azithromycin can improve the patients with pulmonary function,improve the patients quality of life.