2型糖尿病患者中高尿酸血症与慢性肾脏病的相关性研究

RELATIONSHIP BETWEEN HYPERURICEMIA WITH CHRONIC KIDNEY DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

目的探讨2型糖尿病（T2DM）中高尿酸血症与慢性肾脏病的关系。方法采用横断面分析的方法分析了3 250例2型糖尿病患者中高尿酸血症（HUA）与慢性肾脏病的关系。结果纳入研究的2型糖尿病患者中男2 313例,女679例;年龄24-91岁,平均（60.20±9.83）岁,女性（59.25±8.60）岁、男性（60.47±10.13）岁。高尿酸血症的患病率为11.5%,慢性肾脏病患病率为21.6%;高尿酸血症组慢性肾脏病患病率高于正常血尿酸组（15%VS 10.5%,P值均〈0.01）,女性高尿酸血症和慢性肾脏病患病率均高于男性（14.3%VS 10.6%和25.3%VS 20.4%,P值均〈0.01）。女性在血尿酸水平第二四分位组和第四四分位组慢性肾脏病发病率高于男性。Logistic回归分析发现高龄（年龄〉60岁）、高尿酸血症和T2DM患者CKD发生相关。结论在T2DM患者,高尿酸血症与慢性肾脏病有关,女性高尿酸血症组慢性肾脏病发病率高于男性。

Objective To explore the relation of hyperuricemia with chronic kidney disease in type 2 diabetes mellitus.Methods The patients with type 2 diabetes mellitus aged 24-91 years old（n=3 250）were screened by means of cross-sectional study.To assess renal function,eGFR was calculated using CKDEPI equation for the Chinese population.Patients with eGFR 〈60mL/min/1.73m2 were classified as having reduced renal function or chronic kidney disease（CKD）in this study.The clinical and laboratory data were analyzed to explore the relation of chronic kidney disease with hyperuricemia（HUA）in T2 DM.Results In all cohort,the prevalence rate of HUA and of CKD,respectively,was 11.5%and21.6%.In the HUA group,the prevalence of CKD was significantly higher than in normal uric acid group（15% VS10.5%,P〈0.01）.The prevalence rate of HUA and of CKD was higher in female than that in male（14.3% VS 10.6%,25.3% VS 20.4%,P〈0.01）.CKD was only positively related to aged and HUA shown by logistic regression analysis.Conclusion The HUA contribute to the occurrence of CKD in T2 DM,especially in male.