摘要
以二氯甲烷为溶剂,1,4-二氮杂二环[2.2.2]辛烷为催化剂,取代靛红,芝麻酚和丙二腈经三组分Michael-环化反应合成了16个新型的芝麻酚并吡喃螺环氧化吲哚拼接衍生物——6-胺基-5＇-取代基-1＇-取代基-2＇-氧-7＇-取代基螺环[1,3]-二氧亚甲基-[4,5-并]-苯并吡喃-8,3＇-吲哚基]-7-腈,产率85%~96%,其结构经1H NMR,13C NMR和HR-ESI-MS表征。讨论了底物上的取代基对反应速度和产率的影响。
Sixteen novel spiro-fused pyranyl benzo [ d] [ 1,3 ] dioxol oxindole derivatives, 6-amino-1 ＇- substituting group-2＇-oxospiro { [ 1,3 ] dioxolo [ 4,5-g ] chromene-8,3 ＇-indoline } -7-carbonitrile, were synthesized in yield of 85% - 96% by tandem Michael-cyclization reaction of sesamol, malononitrile and substituted isatins, using methylene chloride as the solvent, 1,4-diazabicyclo [ 2.2. ：2 ] octane as the catalyst, at room temperature. The structures were characterized by 1H NMR, 13C NMR and HRESI-MS. Relationship of reaction speed, yields and substituent groups in reactions were investigated.
出处
《合成化学》
CAS
CSCD
2015年第7期599-602,共4页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金青年基金资助项目(21302024)
教育部"新世纪人才支持计划"项目[教技函(2011)95号]
贵州省中药现代化科技产业研究开发专项项目{黔科合ZY字[2013]3010}
贵州民族药物中新颖活性组分的结构测定及NMR谱仪的应用研发项目(2011YQ12003506)
贵州省药食同源植物资源研究开发中心项目{[2014(4003)]黔科合字}
