摘要
以甘氨酸为原料,经酯化和肟化反应制得2-氯-2-肟乙酸乙酯(3);以1,3-二甲基-1,3-二(磺酸丁基)咪唑啉酮硫酸氢根功能性离子液体{[DBSDMI]2HSO4}为催化剂,3与1,1-二苯基乙烯经1,3-偶极环加成反应合成了双苯噁唑酸,总收率63.2%,其结构经1H NMR,13C NMR和ESI-MS确证。
Isoxadifen-ethyl in total yield of 63.2% was synthesized by 1,3-dipolar cycloaddition of 1, 1-diphenyl ethylene with 2-chloro-2-oxime ethyl acetate, which was obtained by esterification and oximation, using glycine as the material and [ DBSDMI] 2HSO4 as the catalyst. The structure was confirmed by 1H NMR, 13C NMR and ESI-MS.
出处
《合成化学》
CAS
CSCD
2015年第7期630-632,共3页
Chinese Journal of Synthetic Chemistry
基金
浙江省科技厅资助项目(2012R10043-08)
关键词
双苯噁唑酸
1
1-二苯基乙烯
合成
工艺改进
Isoxadifen-ethyl
1,1-diphenyl ethylene
synthesis
process improvement
