走近放射性药物化学——学习和认识正电子核素标记的放射性药物

Approaching Radiopharmaceutical Chemistry:Learning and Acquiring the Knowledge of Positron Radionuclide Labelled Radiopharmaceuticals

正电子核素标记的放射性药物是正电子发射计算机断层显像（positron emission computed tomography,PET）发挥功能的关键因素,其开发和临床转化是PET诊断技术发展的核心技术之一。简要介绍PET显像原理及其安全性、PET与其他医学影像技术的区别,阐述放射性药物合成、标记及其临床应用等相关内容,旨在普及放射性药物及其PET显像技术的相关知识。可供教师选用于教学参考,拓展学生化学应用视野,提升学生科学素养。

The key factors of positron emission computed tomography（PET）are the positron radionuclide labelled radiopharmaceuticals,the development and clinical translation of which are the core techniques of PET molecular imaging diagnostic techniques.The theory,safety,synthesis,labelling,clinical application and the characteristics were briefly introduced in this paper.Our purpose is to popularize the knowledge of positron radionuclide labelled radiopharmaceuticals.It is useful for students to broaden chemical horizon and promote scientific literacy.