N,N-二甲基甲酰胺对介孔二氧化硅空心球结构参数和形貌的影响

Influence of N,N-dimethylformamide additive on structure parameter and morphology of hollow mesoporous silica spheres

采用聚酚醛树脂球(RF)为硬模板,十六烷基三甲基溴化铵(CTAB)作为软模板,考察不同N,N-二甲基甲酰胺(DMF)含量以及晶化温度对介孔二氧化硅空心球(H-BMMs)合成的影响。采用XRD、TEM、低温N2吸附-脱附和FTIR分析产物的结构、形貌、孔道织构参数和骨架结构,并采用高效液相色谱(HPLC)法考察了H-BMMs装载布洛芬(IBU)的性能。研究表明,制备的H-BMMs具有较高的比面积(1 100 m2/g),并且壁上有孔径大小均匀的蠕虫状短孔道(2.3 nm)。随着DMF含量的增加,H-BMMs的介孔孔道逐渐减小,并且过高的晶化温度会破坏HBMMs的介孔结构。载药动力学研究发现,H-BMMs有较高的载药率(32%)。

Hollow mesoporous silica spheres（ H-BMMs） were prepared under room temperature and hydrothermal condition with different additions of N,N-dimethylformamide（ DMF） by using obtained RF latex and cetyltrimethylammonium bromide（ CTAB） as dual templates. The morphology and structure of H-BMMs were characterized by using XRD,TEM,N2adsorption-desorption and FTIR techniques. In addition,its drug-loading application was preliminary investigated using ibuprofen as a model drug. The results showed that H-BMMs showed high specific surface area（1 100 m2/ g） and narrowpore size distribution centered at 2. 3 nm. Thereafter,the narrowpore size of H-BMMs decreased with the increase of DMF and overhigh crystallization temperature can completely destroy the mesoporous pore. In addition,H-BMMs showed high drug-loading potential（32%）.