钯催化2-苯基吡啶与扁桃酸衍生物偶联反应的研究

Research on Coupling Reaction Between 2-Phenylpyridine and Mandelic Acid Derivatives Catalyzed by Pd-Based Catalyst

以叔丁基氢过氧化物(TBHP)为氧化剂、醋酸钯为催化剂,研究了2-苯基吡啶与扁桃酸衍生物的偶联反应,考察了氧化剂、催化剂和温度对反应产率的影响。结果表明,氧化剂TBHP对反应起着非常重要的作用。2-苯基吡啶和扁桃酸衍生物在该体系发生催化偶联反应,该反应不仅具有特定的区域和化学选择性,而且产率较高。该反应为芳基酮化合物的合成提供了一条新型便捷的途径。

Using TBHP as oxidant,Pd（OAc）2as catalyst,coupling reaction between 2-phenylpyridine and mandelic acid derivatives was studied.The effects of oxidant,catalyst and temperature on the yield of reaction were investigated.Results showed that TBHP played a very important role in this reaction.The catalytic system was applied to the direct catalytic coupling reaction of a series of 2-phenylpyridine and mandelic acid derivatives.The corresponding products with special regio-and chemo-selectivity were afforded in high yield.This reaction provides a novel and efficient route to the synthesis of aryl ketone compounds.