磺丁基醚-β-环糊精/格列本脲包合物的制备

Preparation of butyl ether-β-cyclodextrin and glibenclamide clathrate

目的制备磺丁基醚-β-环糊精/格列本脲包合物,并对其提高药物溶解性和稳定性的作用进行考察。方法采用相溶解度法测定表观稳定常数,中和法制备磺丁基醚-β-环糊精/格列本脲包合物,并对包合物的溶出度进行了考察。结果与格列本脲原料药相比,磺丁基醚-β-环糊精/格列本脲包合物显著提高了药物的溶解度。结论制备格列本脲的环糊精包合物具有良好的实际应用价值。

Objective To prepare butyl ether-β-cyclodextrin and glibenclamide clathrate,and explore their effect on improve the dissolution and stability of drug. Methods Phase solubility method was implemented to determine the apparent stability constant,neutralization was used to prepare butyl ether-β-cyclodextrin and glibenclamide clathrate; The dissolution of inclusion compounds was investigated. Results Compared with the glibenclamide bulk drug,butyl ether-β-cyclodextrin and Glibenclamide clathrate had increased the drug solubility significantly. Conclusion The preparation of butyl ether-β-cyclodextrin and glibenclamide clathrate had good practical application value.