摘要
目的探讨促红细胞生成素(EPO)治疗新生儿中重度缺氧缺血性脑病的疗效。方法中重度缺氧缺血性脑病患儿62例。随机分为对照组和治疗组。对照组30例给予常规治疗,治疗组32例在常规治疗的基础上给予EPO 300IU/Kg,静脉输注,每周3次。对所有患儿临床症状、新生儿神经行为测定(NBNA)评分、脑电图及婴幼儿智能发育量表(CDCC)评分进行测定。结果治疗组意识障碍恢复时间、原始反射恢复时间、肌张力恢复时间治疗组明显短于对照组(P<0.05);治疗组NBNA评分及CDCC评分高于对照组(P<0.05)。结论使用EPO可改善HIE患儿预后。
Objective To explore the effect of erythropoietin（EPO）in the treatment of moderate to severe neonatal hypoxic-ischemic encephalopathy（HIE）.Methods Sixty-two neonatal patients with moderate to severe neonatal HIE were randomly divided into the treatment group（32cases）and the control group（30cases）.The control group was given the routine treatment,while on this basis the treatment group was given EPO 300IU/kg by intravenous drip,3times per week.The clinical symptoms,score of the Neonatal Behavioral Neurological Assessment（NBNA）,EEG and scores of CDCC were evaluated in all cases.Results The recovery time of conscious disturbance,primitive reflexes and muscle tension in the treatment group was significantly shorter than that in the control group（P〈0.05）;the NBNA score and CDCC score after treatment in the treatment group were significantly higher than those in the control group（P〈0.05）.Conclusion Using EPO can improve the prognosis of the neonatal patients with HIE.
出处
《检验医学与临床》
CAS
2015年第14期2001-2002,共2页
Laboratory Medicine and Clinic
基金
四川省卫生厅基金项目(080215)
