血清同型半胱氨酸水平与鼻咽癌的关联性研究

Correlation research of serum homocysteine level and nasopharyngeal carcinoma

目的探讨鼻咽癌患者化疗前后血清同型半胱氨酸(Hcy)水平的变化及其临床意义。方法选择该院已经确诊的鼻咽癌患者58例和健康体检者60例,采用循环酶法测定鼻咽癌患者化疗前后和健康对照组血清Hcy水平。结果鼻咽癌化疗前血清Hcy水平高于鼻咽癌化疗后和健康对照组(Ρ<0.05),鼻咽癌化疗后患者与健康对照组之间血清Hcy水平的差异无统计学意义(Ρ>0.05)。结论鼻咽癌患者血清Hcy水平较健康对照组有不同程度的升高,血清Hcy测定对鼻咽癌的诊断和转归有一定的参考价值。

Objective To explore the change of serum homocysteine（Hcy）level before and after chemotherapy in the patients with nasopharyngeal carcinoma and its clinical significance.Methods The enzymatic cycling assay was adopted to detect the Hcy level in 58 cases of nasopharyngeal carcinoma before and after chemotherapy and 60 persons undergoing the healthy physical examination in our hospital.Results The serum Hcy levels in the patients with nasopharyngeal carcinoma before chemotherapy was higher than that in the patients with nasopharyngeal carcinoma after chemotherapy and the healthy control group（P〈0.5）,the serum Hcy level had no statistical difference between the patients with nasopharyngeal carcinoma after chemotherapy and the healthy control group（P〉0.5）.Conclusion The serum Hcy level in the patients with nasopharyngeal carcinoma is increased to some extent compared with the healthy controls group,serum Hcy measurement has certain reference value for the diagnosis and outcome of nasopharyngeal carcinoma.