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神经肽S受体1在支气管哮喘小鼠肺组织中的表达 被引量：3

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摘要 随着＂生物学-医学模式＂向＂心理-社会-生物医学模式＂的转变,支气管哮喘（哮喘）导致的心理情绪异常对哮喘发作和控制的影响,特别是与焦虑、抑郁的共病现象越来越被重视,可能涉及环境因素和遗传易感性的相互作用,但具体机制仍不清楚.研究结果显示,神经肽S受体（neuropeptide S receptor 1,NPSR1）的第107位发生Asn（天冬酰氨）-Ile（异亮氨酸）突变与哮喘易感性增加有关[1].NPSR1与其配体神经肽S（neuropeptide S,NPS）构成了一种新的神经肽系统,即NPS/NPSR1系统,可参与调节焦虑与抑郁的病理生理过程[2].推测NPSR1可能是哮喘与焦虑、抑郁之间关系的一个桥梁.因此,本研究通过构建哮喘小鼠病理模型,采用实时定量荧光PCR法和Western blot法检测哮喘小鼠肺组织中NPSR1的表达,为进一步研究NPSR1在哮喘发病机制中的作用提供实验室依据.
作者 程哲 刘梦 刘奇 刘莹 蒋天赐 王茜 代灵灵 李鹏飞 王欢
机构地区 郑州大学第一附属医院呼吸与危重症医学科河南省高等学校临床医学重点学科开放实验室
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2015年第7期541-542,共2页 Chinese Journal of Tuberculosis and Respiratory Diseases
基金 河南省教育厅科学技术研究重点项目（13A320697） 河南省卫生科技创新型人才工程（第4083号）
关键词 哮喘小鼠 支气管哮喘 神经肽 肺组织 受体1 心理-社会-生物医学模式 焦虑与抑郁 RECEPTOR
分类号 R562.25 [医药卫生—呼吸系统]
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参考文献11

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二级参考文献19

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共引文献35

同被引文献32

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中华结核和呼吸杂志
2015年 第7期

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