MicroRNA调控高密度脂蛋白的合成及转运

MicroRNAs regulates the high density lipoprotein biogenesis and its transport

血浆高密度脂蛋白（HDL）具有心血管保护作用；但近年研究表明，仅升高血浆HDL胆固醇（HDL—C）水平并不能降低心血管疾病的发生风险；可见，HDL的功能而并非单纯HDL—C水平才是其发挥心血管保护作用的关键。微小核糖核酸（miRNAs）是参与脂质代谢过程的新型调控因子，在HDL生物合成、细胞内胆固醇动员、肝脏HDL摄取与代谢等胆固醇逆向转运关键环节中均发挥了重要作用。对脂质代谢相关miRNAs的深入研究，将有助于进一步探明HDL介导的胆固醇逆向转运过程及血浆HDL—C水平的分子调控机制，从而更科学、更全面的认识HDL在心血管疾病发生、发展中的作用.

High density lipoprotein （HDL） has been considered as an important mediator in favoring cardioprotective effects. However, recent studies revealed that HDL-C-raising therapeutics alone failed to reduce the risk of cardiovascular diseases, suggesting that the HDLfunctionalitymay be more critical for its cardioprotective properties than the simple HDL-C levels, microRNAs （miRNAs）have been identified as the novel regulators of lipid metabolism and played essential roles in the key steps of reverse cholesterol transport, involving in HDL biogenesis, cellular cholesterol mobilization, hepatic HDL uptake and excretion. The intensive research on lipid metabolism-related miRNAs may provide further clarification on the molecular regulatory mechanisms for HDL-mediated reverse cholesterol transport and plasma HDL-C levels, advancing our knowledge on the effects of HDL in pathogenesis and progression of cardiovascular diseases.