脑梗死溶栓后血清超敏C反应蛋白水平变化的研究

Changes of serum high-sensitivity C-reactive protein after thrombolysis therapy of acute cerebral infarction

目的:探讨急性脑梗死(ACI)溶栓后血清超敏C反应蛋白(hs-CRP)水平变化与预后的关系。方法:50例ACI患者,按梗死体积分为小梗死组(≤5cm3)和大梗死组(>5cm3);按神经功能缺损评分(NIHSS评分)分为轻度损伤组(≤12分)和重度损伤组(>12分);采用乳胶凝集比浊法测定50例ACI患者阿替普酶溶栓前后血清hs-CRP,比较不同组间血清hsCRP变化。结果:ACI患者阿替普酶溶栓后血清hs-CRP水平较溶栓前显著下降;大梗死组较小梗死组明显,重度损伤组较轻度损伤组明显;差异均具有统计学意义(P<0.05)。结论:血清hs-CRP与ACI的病变严重程度、预后有关。

Objective：To explore the association between the high--sensitivity C--reactive protein （hs-- CRP） and the prognosis of acute cerebral infarction （ACI） after thrombolysis therapy. Methods： Serum concentration of hs--CRP were determined by latex agglutination turbidimetric method in 50 ACI patients, and the samples were divided according to infarction volume and NIHSS score.The changes of serum hs-- CRP concentration were compared. Results： The level of serum hs--CRP in acute cerebral infarction was decreased obviously after thrombolysis therapy,it was more decreased in large volume group and severe group than that in small volume group and slight group （P〈0.05）. Conclusion： The hs--CRP level may be related with the severity and prognosis of acute cerebral infarction.