我国HBV、HCV重叠感染与原发性肝癌关系的Meta分析

Meta-analysis of the association between super infection of HBV,HCV and primary liver cancer in China

目的:综合分析不同研究结果,探讨我国人群乙型肝炎病毒(hepatitis B virus,HBV)及丙型肝炎病毒(hepatitis C virus,HCV)重叠感染与肝癌的相关程度。方法:采用Meta分析,对我国2000年以来公开发表的有关HBV、HCV重叠感染和原发性肝癌关系的18篇病例对照研究文献进行定量综合分析,利用Stata12.0中的Meta分析模块进行数据处理。发表偏倚的识别采用漏斗图和Egger's检验。结果:异质性检验发现:P=0.000,df=14,提示入选文献存在异质性。采用随机效应模型进行Meta分析,合并的OR为25.71(95%CI为12.50-52.89)。结论:HBV、HCV重叠感染与原发性肝癌的发生存在高度相关。

Objective： To investigate the correlation between HBV,HCV infection and primary liver cancer in Chinese population. Methods： Meta-analysis was used to quantitatively evaluate 18 public papers of relationship between HBV,HCV infection and primary liver cancer from 2000 to 2012. Data extracted from the papers was analyzed with Stata12. 0. Results： The tests for heterogeneity found,P = 0. 000,df = 14,which suggested that selected literatures existed heterogeneity. Random effect model of Meta-analysis showed the combined OR value = 25. 71（ 95% CI：12. 50-52. 89）. Conclusion： A high correlation was observed between HBV,HCV infection and the incidence of primary liver cancer.