奥施康定治疗45例儿童重度癌痛临床疗效及安全性观察

Therapeutic effect and safety of oxycontin in the treatment of 45 pediatric cases with severe cancer pain

目的:观察奥施康定治疗儿童癌痛临床疗效及安全性。方法:应用奥施康定治疗45例重度癌痛患儿,奥施康定初始剂量10mg/12h。每24h根据病情、镇痛效果进行剂量滴定一次,24h如疼痛分数下降不至3分以下(含3分),且每日突破性疼痛大于2次,则第二天加前1天剂量的25%-50%。结果:45例患者奥施康定用药最小剂量10mg/12h,最大剂量60mg/12h,中位数40mg/12h。治疗后疼痛控制总有效率为100%。主要不良反应为便秘、恶心、头昏、嗜睡、皮肤瘙痒,均为轻中度,无重度不良反应发生。结论:奥施康定对儿童癌痛镇痛效果好、毒副作用小、疗效确切、安全性高。

Objective： To observe the therapeutic effect and safety of Oxycontin in the treatment of 45 pediatric cases with severe cancer pain. Methods： 45 pediatric cases with severe cancer pain were treated with Oxycontin. Oxycontin was administered at an initial does of 10 mg /12 h,and titrated every 24 hours according to the pain control and the adverse reactions. The second day,if score of pain decreased no less than 3（ including 3 scores） and breakthrough pains are greater than 2 times,the total daily Oxycontin dose were increased by 25% to 50% of the before dose. Results： Among the 45 pediatric cases with severe cancer pain,the maximum dose of oxycontin was 10 mg /12 h,the minimum was 60 mg /12 h and the media was 40 mg /12 h. Total pain relief rate was 100%. The main adverse reactions were constipation,nausea,dizziness,somnolence,itch of skin,which were mild or moderate adverse effects,no severe adverse effect. Conclusion： Oxycontin showed good therapeutic effect in the treatment of pediatric cases with severe cancer pain,with mild adverse reactions,and high clinical safety.