洛铂胸腔灌注联合局部热疗治疗恶性胸腔积液的临床观察

Clinical observation of Lobaplatin combined with local thermotherapy in the treatment of malignant pleural effusion

目的:观察洛铂胸腔灌注联合局部热疗治疗非小细胞肺癌(NSCLC)恶性胸腔积液的临床疗效。方法:将50例NSCLC恶性胸腔积液的患者随机分为两组,采用胸腔穿刺术置入中心静脉导管引流胸腔积液,待排尽胸腔积液后,对照组给予胸腔灌注洛铂,实验组在对照组的基础上给予患者局部热疗,比较两组治疗情况、毒副反应及生活质量改善情况。结果:两组患者治疗后,实验组患者的生活质量KPS评分及临床疗效均明显高于对照组(P<0.05),且毒副反应明显少于对照组(P<0.05)。结论:洛铂胸腔灌注联合局部热疗治疗NSCLC恶性胸腔积液的疗效显著、毒副反应小,值得临床推广。

Objective： To observe the clinical effect of Lobaplatin combined with local thermotherapy for the treatment of NSCLC with malignant pleural effusion. Methods： To divide 50 NSCLC patients with malignant pleural effusion into two groups randomly,all patients were treated with thoracentesis and inserted central venous catheter to drainage of pleural effusion. After exhaustion of pleural effusion,the control group was treated with Lobaplatin by pleural perfusion,the trial group was treated with local thermotherapy on the base of the control group. The treatment,side effect and quality of life were compared. Results： After treatment,in was the trial group the KPS score of living quality and the total effective ratio of controlling pleural effusion was significant higher than the control group（ P〈0. 05）,and the side effect was significant lower than the control group（ P〈0. 05）. Conclusion： Lobaplatin pleural perfusion combined with local thermotherapy has significant curative effect and less side effect in the treatment of NSCLC with malignant pleural effusion.