NIBP在胃癌组织中的表达及其与胃癌发生发展的关系

NIBP expression in gastric carcinoma and its relationship with gastric tumorigenesis and progression

目的:检测NIBP(NIK and IKKβbinding protein,NIBP)在胃癌组织中的表达水平,探讨其与胃癌发生发展及预后之间的关系。方法:应用免疫组织化学染色法检测组织芯片中123例胃癌和123例相匹配的癌旁良性胃组织中NIBP蛋白的表达水平。结果:胃癌组织中肿瘤细胞NIBP蛋白表达水平明显高于癌旁良性胃组织上皮细胞(P=0.000),NIBP蛋白在正常胃黏膜和浅表性胃炎、萎缩性胃炎伴肠上皮化生及胃癌组织中的表达水平逐渐升高(P=0.000)。NIBP蛋白表达水平与Lauren分型(P=0.000)、WHO分型(P=0.000)和肿瘤的侵犯深度(P=0.002)显著相关,与年龄、性别、淋巴结转移、远处转移、临床分期无关。生存分析显示NIBP蛋白表达水平与总生存期无明显相关(P=0.552)。结论:NIBP可能参与胃癌的发生发展,在胃炎向胃癌发展的级联过程中发挥重要作用。NIBP可能是胃癌治疗新的潜在的分子靶点。

Objective： To measure the expression of NIK and IKKβ binding protein（ NIBP） in gastric carcinoma and to determine its association with gastric tumorigenesis,progression and prognosis. Methods： Immunohistochemistry for NIBP was done on tissue microarray containing 123 cases of gastric carcinoma and 123 cases of adjacent matched benign gastric tissues. Results： Tumor cells NIBP expression was significantly increased in gastric carcinoma compared with benign gastric mucosa superficial epithelium cells（ P = 0. 000）. NIBP expression was progressively increased in normal gastric tissue and chronic superficial gastritis,chronic atrophic gastritis with intestinal metaplasia and gastric carcinoma（ P = 0. 000）. Tumor cells NIBP expression was found to be significantly correlated with Lauren classification（ P = 0. 000）,WHO classification（ P = 0. 000） and depth of invasion（ P = 0. 002）,but was unrelated to age,gender,presence of lymph node metastases,distant metastasis and clinical stage. Survival analysis showed that NIBP expression was not associated with overall survival（ P = 0. 552）. Conclusion： NIBP is likely to play an important role in gastric carcinoma tumorigenesis,progression and classical chronological cascade of human multistage gastric carcinogenesis. NIBP may be an attractive target for gastric carcinoma treatment.