磁场对骨髓间充质干细胞分化的影响

Effects of magnetic fields on the differentiation of bone marrow mesenchymal stem cells

背景:骨髓间充质干细胞具有多向分化潜能,其中磁场对骨髓间充质干细胞分化的影响近年来吸引了相当多的关注。目的:综述磁场对骨髓间充质干细胞向成骨细胞、软骨细胞、脂肪细胞、神经细胞和心肌细胞方向分化的影响,为组织工程种子细胞的研究应用和临床应用磁场的治疗提供参考。方法:由第一作者检索2000至2015年PubM ed数据库以及中国知网数据库有关磁场对骨髓间充质干细胞分化影响的文献,并进行系统整理、总结和分析,最终保留40篇文献进行分析。结果与结论:磁场可以促进骨髓间充质干细胞向成骨细胞、软骨细胞、神经细胞和心肌细胞等方向的分化,可以抑制骨髓间充质干细胞向脂肪细胞方向分化。磁场对骨髓间充质干细胞的诱导分化作用有最适频率和磁场强度,一般来说,较低强度、较低频率的磁场有更明显的诱导作用,磁场对骨髓间充质干细胞分化的影响也具有一定的时间依赖性。

BACKGROUND： Bone marrow mesenchymal stem cells have the ability to differentiate into a variety of non-hematopoietic tissue cells. Effects of magnetic fields on the differentiation of bone marrow mesenchymal stem cells have attracted a lot of attention in recent years.OBJECTIVE： To summarize the effects of magnetic fields on the differentiation of bone marrow mesenchymal stem cells towards osteoblasts, chondrocytes, adipocytes, nerve cells and cardiomyocytes, which provide references for the research and application of tissue engineering seed cells as well as the clinical applications of magnetic fields.METHODS： The first author performed a data retrieval of PubM ed and CNKI databases from 2000 to 2015 to search the articles addressing the effects of magnetic fields on the differentiation of bone marrow mesenchymal stem cells, and reviewed the literatures systematically. Finally, 40 articles were chosen for further analysis.RESULTS AND CONCLUSION： Magnetic fields can promote the differentiation of bone marrow mesenchymal stem cel s towards osteoblasts, chondrocytes, nerve cells and cardiomyocytes, and inhibit the differentiation of bone marrow mesenchymal stem cel s towards adipocytes. There are optimal frequency and intensity in the induction of magnetic fields on the differentiation of bone marrow mesenchymal stem cel s. In general, low-intensity and low-frequency magnetic fields have more obvious effects on bone marrow mesenchymal stem cel s. The facilitation of magnetic fields on the differentiation of bone marrow mesenchymal stem cells is also a time-dependent behavior.