肾功能不全对急性冠脉综合征患者远期预后的影响

Effect of renal dysfunction on long term prognosis of patients with acute coronary syndrome

目的探讨肾功能不全对急性冠脉综合征患者远期预后的影响。方法选取260例急性冠脉综合征患者为研究对象,依据肾小球滤过率(e GFR)分为e GFR正常组和e GFR降低组。观察两组基础性疾病和严重心血管事件发生情况。结果 e GFR降低组急性冠脉综合症患者合并高血压、糖尿病、缺血性疾病、高血脂等基础性疾病发生率均高于e GFR正常组,差异有统计学意义(P<0.05);严重心血管不良事件发生率高于e GFR正常组,但差异未见统计学意义(P<0.05)。结论急性冠脉综合征合并肾功能不全患者高血压、糖尿病等基础性疾病发生率高,极易发生心源性死亡等严重心血管不良事件,病死率高,远期预后差。

Objective To investigate the effect of renal dysfunction on long term prognosis of patients with acute coronary syndrome. Methods Two hundred and sixty patients with acute coronary syndrome were chosen as the objects. According to glomerular filtration rate（ e GFR）,the patients were divided into normal e GFR group and reduced e GFR group. The basic diseases and serious cardiovascular events were observed. Results The incidences of acute coronary syndrome complicated with hypertension,diabetes,ischemic disease,hyperlipidemia and other basic diseases were higher in the reduced e GFR group than those in the normal e GFR group,there were significant differences（ P〈0. 05）. The rate of serious cardiovascular events in the reduced e GFR group was higher than that of the normal e GFR group,but there was no significant difference（ P〈0. 05）.Conclusion The incidence of hypertension,diabetes with other basic diseases in patients with acute coronary syndrome and renal insufficiency is high,and it is prone to sudden cardiac death and other serious cardiovascular adverse events. The mortality rate is high with poor prognosis.