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血小板-白细胞相互作用在心血管疾病中的研究进展 被引量：2

Progress of study on interaction between platelets and leukocyte in cardiovascular disease
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摘要 血小板-白细胞相互作用是血小板和不同类型白细胞进行信号转导引起互相聚集,互相活化的细胞过程,目前主要机制与选择素和CD40/CD40L相关。近年研究发现血小板激活后表达多种黏附分子、趋化因子及细胞因子并改变白细胞生物学功能,影响高血压、心力衰竭等多种心血管疾病发生与发展。通过本文对其基本机制及在心血管疾病中的影响做一简要综述。 Platelets-leukocyte interactions is a cell process which is characterized by the exchange of signals between platelets and different types of leukocytes,and finally contribute to interactivate and intergather. The study identified it is associated with the selectin and CD40 / CD40 L. In recent researches discovered activated platelets can express adhesion molecules,and cytokines,which changed the leukocyte biological function,and influenced the development of cardiovascular disease. This review summarizes the basic molecular mechanisms of platelet-leukocyte communication and the influence in cardiovascular disease.
作者 钱仁怡 魏国清 孟照辉
机构地区 昆明医科大学第一附属医院分子心血管病研究室
出处 《临床医学》 CAS 2015年第6期113-115,共3页 Clinical Medicine
基金 国家自然科学基金资助项目(30860278 81160025) 云南省应用基础重点项目(2012FB005) 云南省中青年学术技术带头人后备人才资助项目(2011CI05) 云南省卫生领军人才培养计划(L-201203)
关键词 血小板 白细胞 相互作用 心血管疾病 Platelets Leukocytes Interaction Cardiovascular disease
分类号 R54 [医药卫生—心血管疾病]
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参考文献34

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二级参考文献14

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临床医学
2015年 第6期

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