黄体酮与地塞米松对胎膜早破相关因子的比较研究

Comparative study of related factors of premature rupture of membranes by progesterone and dexamethasone

目的探讨黄体酮对胎膜早破孕妇外周血促肾上腺皮质激素释放激素(CRH)及分娩时间的影响。方法选取河南省人民医院妇产科已确诊为胎膜早破患者80例,随机分为地塞米松(DEX)组、地塞米松加黄体酮(DEX+P)组、黄体酮(P)组和对照组,检测3组患者入院时、入院24 h、入院48 h外周血白细胞计数、C-反应蛋白、CRH水平以及分娩时间、新生儿体质量,并且分析CRH水平与分娩时间的相关性。结果与其他3组相比较,DEX组患者外周血CRH水平更高(P<0.05);CRH升高更快(P<0.05);分娩时间更短(P<0.05);CRH水平与分娩时间呈负相关关系(r=-0.832,P<0.05)。结论地塞米松治疗能够使胎膜早破孕妇外周血CRH水平上升,分娩时间缩短,黄体酮可以抑制此过程。

Objective To analyse the effect of progesterone on peripheral blood corticotropin releasing hormone （ CRH ） and delivery time in women with premature rupture of membranes （ PROM ） .Methods 80 patients who were diagnosed with PROM in Department of Obstetrics and Gynecology, China Medical University were collected.Randomly divided into dexamethasone （DEX） group, dexamethasone plus progesterone （DEX＋P） group, progesterone （ P） group and control group, three groups were detected on admission, admission 24 h, 48 h on peripheral white blood cell count, C-reaction protein, CRH level and time of delivery, neonatal weight, and analysis of CRH the level of the correlation and delivery time.Results Compared with the other three groups, the level of CRH in peripheral blood of DEX group were higher （P〈0.05）;CRH （P〈0.05） increased faster;shorter delivery time （P〈0.05）; the level of CRH was negatively correlated with delivery time （r=-0.832, P〈0.05）.The results were statistically significant.Conclusion Dexamethasone treatment can make the premature rupture of fetal membranes of peripheral blood CRH levels rise, shorten the delivery time, progesterone can inhibit this process.