组织多肽特异性抗原与血管内皮生长因子与乳腺癌患者病理分级关系研究

Study on expression of TPS,VEGF of beast cancer patients and relationship with clinical pathological

目的探讨乳腺癌患者血清中组织多肽特异性抗原(TPS)、血管内皮生长因子(VEGF)的表达及其与临床病理关系的研究。方法选取收治的原发性乳腺癌女性患者68例,乳腺纤维瘤的女性患者36例作为对照组。采用ELISA检测法检测2组患者血清中TPS和VEGF水平,比较实验组TPS和VEGF水平与TNM分期及临床病理特征的关系。结果实验组患者TPS和VEGF水平明显高于对照组,差异有统计学意义(P<0.05);术后实验组TPS、VEGF水平低于术前水平(P<0.01);TPS、VEGF水平在乳腺癌0期与Ⅰ期中差异无统计学意义;随着肿瘤分期增加,TPS、VEGF上升(P<0.05);VEGF表达水平在肿瘤直径≤2 cm组明显低于肿瘤直径>2 cm组(P<0.05)。腋下淋巴结转移组与腋下淋巴结无转移组患者血清中TPS和VEGF浓度差异有统计学意义(P<0.05)。TPS浓度水平在雌激素受体阴性、孕激素受体阴性中明显高于雌激素和孕激素阳性组(P<0.05)。结论乳腺癌患者血清中TPS、VEGF水平呈现高表达状态,TPS、VEGF水平表达与乳腺癌患者腋窝淋巴结转移、雌激素受体、孕激素受体有关。

Objective To investigate expression of TPS, VEGF of beast cancer patients and relationship with clinical pathological.Methods 68 cases of breast cancer were selected as experiment group, 36 cases with breast fibroma were selected as control group.TPS and VEGF were detected by elisa of patients before and after treatment.Serum TPS and VEGF levels and TNM staging were compared after operation.Results TPS and VEGF of the experiment group were higher than control group（P〈0.05）.TPS and VEGF of experiment group after operation were higher than before operation.TPS and VEGF increased with the grade of tumor, but there was no significance between grade Ⅰ and 0.The expression of VEGF in tumor diameter≤2 cm group was significantly lower than 〉2 cm group（P〈0.05）.TPS and VEGF of axillary lymph node metastasis group and axillary lymph node metastasis had significant difference（P〈0.05）.The concentration of TPS was significantly higher than that of estrogen and progesteronepositive group in estrogen receptor negative, progesterone receptor negative （P〈0.05）.Conclusion TPS, VEGF levels in the serum of breast cancer patients showed high expression, the expression of TPS, VEGF levels related to axillary lymph node metastasis, estrogen receptor, progesterone receptor.