分泌型IgA联合加味玉屏风散治疗急性小儿上呼吸道感染的疗效评价

Evaluation on clinical effect of sIgA combined with Jiawei Yuping Feng pulvis in treatment of upper respiratory infection in children

目的探讨分泌型Ig A（sIgA）联合加味玉屏风散治疗急性小儿上呼吸道感染的疗效。方法选择浙江省杭州市杭区第一人民医院上呼吸道感染的住院患儿160例,随机分为治疗组和对照组各80例,2组患儿均给予常规的对症及补液治疗,对照组给予中药加味玉屏风散,2次/天,每次3 g,口服;治疗组在此基础上,予分泌型Ig A滴鼻,0.3-0.5 mg/（kg·d）,分6-8次。2组疗程均为7 d。观察2组治疗1个疗程后的总有效率,2组患儿的症状改善时间和2组不良反应的发生率。结果治疗组总有效率（96.25%）显著高于对照组（85.00%）（χ^2=5.96,P〈0.05）;治疗7 d后,治疗组的WBC和中性粒细胞百分率（neutrophil granulocyte ratio,NEUT%）较对照明显下降（P〈0.05）;治疗组中患儿发热、咳嗽咳痰、咽痛及鼻塞流涕症状缓解时间显著少于对照组（P均〈0.05）;2组的不良反应率均较低。结论分泌型Ig A联合加味玉屏风散治疗小儿上呼吸道感染疗效确切,不良反应少。

Objective To investigate clinical effect of sIgA combined with Jiawei Yuping Feng pulvis in treatment of upper respiratory infection （ URI） in children.Methods 160 children in hospital diagnosed with URI were randomly divided into treatment group and control group.With basic treatment, the control group were treated with Jiawei Yuping Feng pulvis, twice per day, 3 g each time, orally; treatment group on the basis of control group, secretory IgA via nasal drip, 0.3-0.5 mg/（ kg？ d） , dividing into 6-8 times.The treatment course was 7 days.The total efficiency, improvement of symptoms and adverse reactions were observed and compared.Results The total effective rate of treatment group （96.25%） was significantly higher than control group （85%）（χ^2 =5.96, P〈0.05）.After 7 days of treatment, WBC and NEUT% of treatment group decreased significantly compared with control group （ P 〈0.05 ） .The fever, sore throat and runny nose, cough and expectoration symptom remission time of treatment group were significantly shorter than control group （P〈0.05）.Adverse reactions of both groups were lower.Conclusion It is effective to treat URI in children using sIgA combined with Jiawei Yuping Feng pulvis therapy, and it has few adverse reactions.