摘要
耐甲氧西林金葡菌(MRSA)是一种重要的人类病原体。过去MRSA感染仅在医院中发生,近年来MRSA开始向社区和畜牧养殖场蔓延。本文简要介绍与MRSA相关的致病因子,综述其中研究较多的4种毒力因子(Sas X蛋白、杀白细胞素、酚溶解调控蛋白和精氨酸分解代谢可动元件)的最新进展。
Methicillin-resistant Staphylococcus aureus （MRSA） remains a prominent human pathogen. Usually, MRSA infection is occurred exclusively in hospitals. However, recently MRSA is also occurred in community and livestock farm. To understand the mechanism for enhanced virulence of MRSA can really help to defeat this superbug. This review describes the virulence factors of MRSA, and introduces the recent progress made towards four virulence determinants, which are SasX protein, Panton-Valentine leukocidin（PVL）, phenol-soluble modulins （PSM） and arginine catabolie mobile element（ACME）.
出处
《世界临床药物》
CAS
2015年第7期442-446,共5页
World Clinical Drug
基金
国家"重大新药创制"科技重大专项(2012ZX09304004
2014ZX09507009-025)
国家自然科学基金(81273413
81373310)
