血清蛋白因子水平对精神分裂症及抑郁症的诊断价值

Diagnostic value of serum protein factor levels to schizophrenia and depression

目的：探讨血清蛋白因子检测对精神分裂症与抑郁症的临床诊断价值。方法将120例精神分裂症患者设为A组、120例抑郁症患者设为B组、120名健康体检者设为C组，对3组被试血清脑源性神经营养因子、血清神经生长因子、髓鞘碱性蛋白、钙结合蛋白、白细胞介素6、肿瘤坏死因子α、干扰素‐γ、神经角质纤维酸性蛋白水平进行检测分析。结果 A组、B组血清髓鞘碱性蛋白及脑源性神经营养因子水平显著低于C组（P＜0．01），A组显著低于B组（P＜0．05或0．01）；A组血清神经生长因子水平显著低于B组、C组（ P＜0．01），B组与C组比较差异无显著性（P＞0．05）；A组血清白细胞介素6水平显著高于B组、C组（P＜0．01），B组与C组比较差异无显著性（P＞0．05）；A组、B组血清钙结合蛋白水平显著高于C组（P＜0．01），A组显著低于B组（P＜0．01）。结论血清蛋白因子水平变化与精神分裂症及抑郁症的病理生理、临床表现密切相关，检测血清蛋白因子水平对于精神分裂症及抑郁症的诊断具有重要意义。

Objective To explore the diagnostic value of serum protein factor levels to schizophrenia and depression .Methods A total of 120 patients with schizophrenia were assigned to group A ,120 ones with depression to group B and 120 healthy persons to group C ,detections and analyses carried out on the ser‐um levels of BDNF ,NGF ,myelin basic protein （MBP） ,CaBP ,IL‐6 ,TNF‐α,IFN‐γand GFAP .Results Serum MBP and BDNF levels were significantly lower in group A and B than in C （ P〈0 .01） ,so were those in A than in B （P〈0 .05 or 0 .01）;serum NGF level was significantly lower in group A than in B and C （P〈0 .01） ,there was no significant difference between group B and C （P〉0 .05）;serum IL‐6 level was significantly higher in group A than in B and C （P 〈0 .01） ,there was no significant difference between group B and C （P〉 0 .05）;serum CaBP levels were significantly higher in group A and B than in C （P〈0 .01） ,that was significantly lower in A than in B （P〈0 .01） .Conclusion The changes of serum protein factor levels are closely related to pathophysiology and clinical manifestations of schizophrenia and depres‐sion ,detections of serum protein factor levels have an important significance for the diagnosis of schizo‐phrenia and depression .