腹腔循环热灌注联合静脉化疗在胃癌合并腹腔积液的应用

Application of abdominal circulating hot perfusion combined with intravenous chemotherapy in gastric cancer combined with abdominal cavity effusion

目的探讨腹腔循环热灌注联合静脉化疗在胃癌合并腹腔积液中的应用效果。方法选择南阳市中心医院2011年1月至2013年12月收治的70例胃癌合并腹腔积液患者为研究对象，随机分为两组，对照组患者行单纯静脉化疗，观察组患者行腹腔循环热灌注联合静脉化疗，对两组临床疗效、不良反应及1年复发率进行比较。结果观察组治疗有效率71．4％，与对照组的45．7％比较差异有统计学意义（P〈0．05）。另外，观察组不良反应发生率、1年复发率分别为42．9％及31．4％，明显低于对照组的68．6％、71．4％，差异有统计学意义（P〈0．05）。结论腹腔循环热灌注联合静脉化疗效果良好，能有效减少不良反应，降低复发率，值得临床推广。

Objective To investigate the application effect of abdominal circulating hot perfusion combined with intravenous chemotherapy on gastric cancer combined with abdominal cavity effusion. Methods Seventy cases of gastric cancer combined with abdominal cavity effusion from January 2011 to December 2013 were chosen as research objects, and randomly divided into two groups, the patients in control group were given vein chemotherapy, and the patients in observation group were given abdominal circulating hot perfusion combined with intravenous chemotherapy. The clinical curative effects, adverse reactions and 1 year recurrence rates of the two group were combared. Results The effective rate of ob- servation group was 71.4%, compared with that of control group（45.7% ）, difference was significant （P 〈 0. 05 ） ; the incidence of adverse reactions and 1 year recurrence rate of observation group was 42. 9% and 31.4%, which was significantly lower than that of the control group 68.6%, 71.4%, the differences were significant （P 〈 0. 05 ）. Conclusions The effect of abdominal circulating hot perfusion combined with intravenous chemotherapy is good, and it can effectively reduce the adverse reaction, reduce the recurrence rate, so it is worthy of clinical promotion.