成都地区健康体检人群女性亚临床甲减与代谢综合征各组分的相关性研究

The Correlation Study between Subclinical Hypothyroidism with the Components of Metabolic Syndrome of the Female Having Health Examination in Chengdu

目的了解甲状腺功能减退症和代谢综合征(MS)在女性人群中的相关性。方法对2011至2012年在我院进行健康体检并行甲状腺功能检测的4488例女性进行调查。其内容包括采集患者的病史、血压、身高、体重、甲状腺功能、空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇、上腹彩超中脂肪肝的患病数据等。统计分析采用SPSS 18.0软件。结果 4488例中共发现亚临床甲状腺功能减退患者936例,占20.86%。60岁以上人群的患病率高于其他年龄段,差异有统计学意义(P<0.01)。亚甲减组出现MS及轻度代谢异常的比例明显高于甲功正常组,差异有统计学意义(P<0.05)。MS各组分除空腹血糖,其余各指标甲功正常组均优于亚甲减组,差异有统计学意义(P<0.05)。两组中空腹血糖差异无统计学意义(P>0.05)。脂肪肝的患病率:甲功正常组<亚甲减组<甲减组,差异有统计学意义(P<0.05)。结论女性亚临床甲减患者发生MS的可能性较正常人群明显增高,女性亚临床甲减的患病与血脂、血压、体重指数、脂肪肝具有相关性。

Objective Analyze the relationship between subclinical hypothyroidism（ SCH） and metabolic syndrome in women. Methods There were 4488 female who did health examination and thyroid function test in West China Hospital of Sichuan University in 2011—2012. Collectmg the information abont the medical history and the result of physical examination; thyroid function,TG,TC,LDL-C,HDL-C,FPG,fatty liver by abdominal ultrasonography. Statistical analysis was carried out with SPSS18. 0. Results There were 936 SCH patients in 4488 women,the prevalence was 20. 86%. The people over 60 years old had the highest SCH prevalence（ P〈0. 01）. The rate of MS in SCH group was higher than the rate in health group. Besides FPG,the other components of metabolic syndrome in health group was better than in SCH group（ P〈0. 05）. The prevalence of fatty liver was health grou PSCH grou PCH group（ P〈0. 05）. Conclusion The probability of MS occurrence in the female SCH patient is increased remarkably than health person. The prevalence of SCH of female is related to blood lipid,blood pressure,body mass index and fatty liver.