类叶升麻苷的药理作用及药物代谢动力学研究进展

Advances in studies of pharmacodynamics and pharmacokinetics of acteoside

目的:总结类叶升麻苷药理作用及药动学研究进展,为开发研究提供参考依据。方法:查阅相关的文献报道进行综述。结果:类叶升麻苷药理作用广泛,尤其是抗氧化、抗衰老、增强记忆和神经保护作用等更为突出。其吸收迅速,生物利用度较低,体内分布广泛且存在系统前代谢情况。结论:类叶升麻苷药理活性强、毒副作用小,具有很好的开发前景。

Objective Summary pharmacodynarnics and pharmacokinetics of aeteoside to provide reference for further development. Method Search and overview the reported relevant literature. Results Acteoside has extensive and potent biological activities, especially the antioxidant, anti - aging, as well as cytoprotective effects and memory - enhancing. And acteoside is absorbed quickly with low bioavailability, extensive distribution and presystemie metabolism. Conclution Acteoside is a promising drug for further research with potent biological activities and low toxicity.