IL-28B基因多态性与HBeAg阳性的慢性乙型肝炎患者干扰素病毒学应答相关性的meta分析

Meta Analysis of the Association of Polymorphism in IL-28B Gene and Virological Response to Interferon in HBe Ag-positive Chronic Hepatitis B

目的研究白细胞介素28B(IL-28B)基因多态性与HBe Ag阳性的慢性乙型肝炎患者应用干扰素病毒学应答的相关性。方法计算机检索Pub Med、Web of Science、China Bio Medicine(CBM)、万方数据库等,由2名评价员独立检索和提取资料并交叉核对,纳入相关病例对照试验。采用Cochrane协作网提供的Rev Man 5.3软件进行meta分析,应用Stata11.0软件进行发表偏倚检验。结果共纳入文献7篇,包括1 345例患者,经过meta分析后发现与rs8099917 TG/GG等位基因相比,rs8099917TT等位基因对于HBe Ag阳性的慢性乙型肝炎患者应用干扰素的病毒学应答无明显差异(P=0.20)。rs12979860 CC与CT/TT等位基因相比对于病毒学应答的发生没有差异(P=0.75)。结论 IL-28B(rs8099917、rs12979860)的基因多态性与HBe Ag阳性慢性乙型肝炎患者应用干扰素达到持续病毒应答无相关性。

Objective To explore the association between the polymorphism in IL-28B gene and the interferon virological response in HBeAg-posi- tive chronic hepatitis B patients. Methods A hterature search was performed on PubMed, Web of Science, China Bio Medicine （CBM） and Wan- Fang database. The references was screened with the inclusion and exclusion criteria, and then data were extracted and methodological quality of the studies was judged. Statistical analysis was carried out with RevMan 5.3 and STATA 11.0. Results Totally 7 publications were recruited for the study, including 1 345 patients. The meta-analysis showed that there was no significant difference of interferon response between HBeAg-positive chronic hepatitis B patients with rsS099917TG/GG alleles and rs8099917TF alleles （P = 0.20）. There was no statistical difference between Rs 12979860CC and CT/TT allele for the sustained virological response （P = 0.75）. Conclusion Our current meta-analysis suggests that there was no correlation of rs8099917, rs12979860 polymorphism in IL-28B with the sustained virological response to interferon in HBeAg-positive chronic hepatitis b.