系统性红斑狼疮患者血脂异常危险因素分析

Analysis on correlation between systemic lupus erythematosus patients with dyslipidemia

目的探讨血脂异常对系统性红斑狼疮患者的意义。方法选取系统性红斑狼疮患者124例，按血脂水平有无异常将患者分别设为观察组84例和对照组40例。观察2组总胆固醇（Tc）、甘油三酯（T）、高密度脂蛋白胆固醇（HDL-）、低密度脂蛋白胆固醇（LDL—L）水平，补体c3、c4水平，血沉速度，肾病、血液病变、抗核酸抗原抗体（ANA）阳性的发生情况。结果观察组患者TC、TG、LDL-L水平高于对照组，HDL-L水平低于对照组，差异均有统计学意义（P〈0．01）。观察组肾病、血液病变、ANA阳性发生率高于对照组，差异有统计学意义（P〈0．01）。观察组补体c3、c4水平低于对照组，观察组血沉速度高于对照组，差异有统计学意义（P〈0．01）。结论系统性红斑狼疮患者血脂异常作为临床参考指标，具有一定的参考价值。

Objective To investigate the correlation between systemic lupus erythematosus patients with dyslipidemia. Methods A total of 124 patients with systemic lupus erythematosus were assigned to observation group （n = 84, with dyslipidemia） and control group （n =40, without dyslipi- demia）. The total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol （HDL- L）, Low density lipoprotein cholesterol （LDL-L）, complement C3and C4, sedimentation rate were observation , as well as incidence of nephropathy, hemopathy and nucleic acid resistant antigen anti- body （ANA） positive. Results The observation group had higher levels of TC ,TG, LDL-L and lower HDL-L compared with the control group （P 〈 0.01 ）. The incidence of nephropathy, hemopathy and ANA positive were higher in observation group than that in control group （P 〈 0.01 ）. the observation group had a lower level of complement C3and C4, but higher sedimentation rate compared with the control group （P 〈 0.01 ）. Conclusion Dyslipidemia may be useful for as an indicator in systemic lupus erythematosus patients.