右丙亚胺联合CAG方案治疗老年急性髓细胞白血病的疗效观察

Dexrazoxane combined with CAG regimen in elderly patients with acute myeloid leukemia

目的探讨右丙亚胺联合CAG方案（阿克拉霉素＋小剂量阿糖胞苷＋粒细胞集落刺激因子）治疗老年急性髓细胞白血病（AML）的疗效。方法选取老年AML患者65例分为观察组（n=35）和对照组（n,=30）。对照组给予CAG方案，观察组在此基础上加用右丙亚胺。结果2组临床疗效及不良反应差异无统计学意义（P〉0．05）。化疗后2组均有心电图异常的发生，但观察组心电图异常发生率低于对照组，差异有统计学意义（P〈0．05）；2组cTnI水平均升高，差异有统计学意义（P〈0．01），观察组低于对照组，差异有统计学意义（P〈0．01）。结论CAG方案是治疗老年AML患者的有效方案，其中右丙亚胺可在不影响疗效的前提下有效减轻化疗相关的心脏毒性。

Objective To investigate the clinical effect of dexrazoxane combined with CAG regimen （low dose cytarabine ＋ aclaeinomycin ＋ granulocyte colony-stimulating factor ） in elderly pa- tients with acute myeloid leukemia （AML）. Methods A total of 65 AML patients were assigned to study group （n = 35 ） and control group （n = 30）. The control group was given CAG regimen and the study group were given dexrazoxanc combined with CAG regimen. Results There was no significant difference in clinical efficacy and incidence of adverse reaction between two groups （ P 〉 0. 05 ）. Study group had higher incidence of abnormal ECG compared with control group （ P 〈 0. 01 ）. The level of cTnI was decreased in both groups and was significant lower in study group than in control group （P 〈 0. 01 ）. Conclusion Dexrazoxane combined with CAG regimen is effective to alleviate chemotherapy induced cardiac toxicity in AML patients.