根尖囊肿病变中的郎格罕氏细胞——25例免疫组织化学研究

Langerhans Cells in Radicular Cysts:An Immunohistochemical Study of 25 Cases

本文采用S—100蛋白和溶茵酶抗体的免疫过氧化物酶染色技术(PAP 法)分析鉴定了25例根尖囊肿病变内的郎格罕氏细胞及其分布特点。研究结果提示细胞介导免疫反应在根尖囊肿的发病机制中可能起重要作用。

Using immunoperoxidase method,antisera to S-100 protein and lysozyme were tested onformalin fixed,paraffin-embedded tissue from 25 radicular cysts in this study.S-100-po-sitive dendritic cells(Langerhans cells)were found in all 25 radicular cysts both in liningepithelium and in connective tissue wall,and their distribution was closely related to the intensity of inflammation and lymphocyte infiltration.Lysozymc-positive cells were foundprcdominantly in connective tissue.Since the primary function of Langerhans cells has be-en shown to be antigen processing and subsequent presentation of relevant determinants toT lymphocytes,the present results provide additional support for the importance of thecellmediated immune response in periapieal disease.