妊娠合并外阴阴道假丝酵母菌病的治疗对胎膜早破预防作用的研究

目的：探讨对妊娠合并外阴阴道假丝酵母菌病的治疗在胎膜早破预防中的应用价值。方法：选取2014～4月到2015年5月我院收治的78例患者，将所有患者分为4组，分别为妊娠合并外阴阴道假丝酵母菌病治疗组，有26例患者；妊娠合并外阴阴道假丝酵母菌病未治疗组10例患者；足月胎膜早破（非阴道炎）组，有22例患者；正常对照妊娠组，有22例患者，对这四组进行干预治疗，观察前两组患者的胎膜早破发生率以及妊娠结局，并对四组患者胎膜中基质金属蛋白酶-9（MMP-9）及金属蛋白酶组织抑制因子-1（TIMP-1）进行免疫组织化学技术进行检测，比较四组检测结果并进行分析。结果：治疗组患者的的胎膜早破发生率低于未治疗组，具有明显差异统计性（P〈0．05）；胎膜早破组患者的MMP-9Pu值及MMP-9／TIMP-1PU比值和未治疗组的结果差异无统计学意义（P〉0．05），但是与治疗组患者以及正常组患者的结果相比，却明显高于后两组（P〈0．05）；各纽患者的的TIMP-1PU值相差不多，比较差异无统计学意义（P〉0．05）。结论：妊娠舍并外阴阴道假丝酵母菌病可以提高胎膜中的MMP-9，进而使胎膜早破发生率提高，增加了危险性，通过对预防妊娠合并外阴阴道假丝酵母菌病进行针对性的治疗可以有效降低胎膜早破的发生率，增加安全性，值得在临床上推广。

Objective： To investigate pregnant women with vulvovaginal candidiasis therapeutic value in the prevention of premature rupture of membranes. Methods ： 2014 - April to May 2015 in our hospital 78 patients, all the patients were divided into 4 groups, namely pregnant women with vulvovaginal candidiasis treatment group, 26 patients; pregnant women with vulvar vaginal candidiasis untreated group of 10 patients ; premature rupture of membranes （non vaginitis） group, 22 patients; normal pregnancy group, 29 patients, these four groups intervention, observation The incidence of premature rupture of membranes before and pregnancy outcomes of two groups of patients, and four patients with fetal membrane matrix metalloproteinase - 9 （ MMP - 9） and tissue inhibitor of metalloproteinase - 1 （ TIMP - 1 ） Immunohistochemistry technology for detection, comparing the four groups and the test results analyzed. Results： The patients of premature rupture of membranes was lower than the untreated group, with a statistically significant difference （P 〈 0.05 ） ; MMP -9 PU value PROM group of patients and MMP - 9 / TIMP - 1 PU ratio difference between the results and untreated groups was not statistically significant （ P 〉 0.05 ）, but the treatment group compared with the control group of patients and patient outcome, was significantly higher than after two （P 〈 O. 05 ） ; each group TIMP - 1 PU patients with almost the same value, the difference was not statistically significant （ P 〉 0. 05 ）. Conclusion ： The pregnant women with vulvovaginal candidiasis can improve fetal membranes of MMP - 9, and thus make in- creased incidence of premature rupture of membranes, increasing the risk, through the prevention of pregnancy with vulvovaginal candidiasis were against of treatment can effectively reduce the incidence of premature rupture of membranes, increased security, it is worth in clinical practice.