老年患者应用抗生素致ADR的临床特点及危险因素Logistic回归分析

目的：探讨老年患者应用抗生素致ADR的临床特点及危险因素Logistic回归分析。方法：选取我院2013年6月～2014年6月收治的老年患者，采集所有患者一般资料，对患者进行感染物培养，分析老年患者使用抗生素ADR临床特点及多因素Logistic回归分析。结果：488应用是抗生素导致ADR患者中，有235例应用B内酰胺类，占64．03％，有134例患者应用喹诺酮类，占3651％，有72例患者应用氨基糖苷类，占14．75％，有34例患者应用大环内酯类，占6．96％，有8例患者应用林可霉素类，占163％，有5例患者应用磺胺类，占1．02％。488例患者中共分离出1000株致病菌，其中有312株为主要的革兰阴性菌，31．2％，有189例患者感染革兰阴性菌，占6057％。有98株真菌，占9．8％。结论：老年患者应用抗生素致ADR危险因素较多，临床应给予针对性预防，加强监测，应用抗生素时尽量减少用量，避免肝肾损伤，同时注意给药个体化，以达到治疗效果。

Objective： to study the clinical characteristics of elderly patients with use of antibiotics to ADR and risk factor from June 2013 to June 2013 treated of elderly pa- tients, and to collect all of the patients in general information, content training for patients with infections, analysis of clinical characteristics of elderly patients with antibiotics ADR and muhiariable Logistic regression analysis. Results： of 488 patients with applications are antibiotics leads to ADR, Conclusion： elderly patients with antibiotics to ADR risk factors, clinical should give targeted prevention, strengthen the monitoring, the use of antibiotics to minimize the dosage, avoid liver and kidney damage, attention to individual at the same time, in order to achieve therapeutic effect.