期刊文献+

阿司匹林联合氯吡格雷治疗非心源性后循环脑梗死的疗效观察

原文传递
导出
摘要 目的:观察阿司匹林联合氯吡格雷治疗非心源性后循环脑梗死的疗效,进一步探讨卒中的分层治疗。方法:选择2012年2月至2014年2月本院神经内科住院的非G源性后循环脑卒中患者148例,在他汀降脂及改善循环的基础上,随机分组并分别给予阿司匹林联合氧吡格雷、阿司匹林治疗2周,观察治疗前后的NIHSS评分变化及疗效比较、副作用情况。结果:观察组和对照组的NIHSS评分及疗效比较均存在显著性差异,均未出现明显不良反应。结论:对于非心源性后循环梗死患者,排除高出血风险之后,双联抗血小板治疗可能可以取得更好的疗效,值得在临床中推广。
出处 《医学与社会》 2015年第B05期177-178,共2页 Medicine and Society
  • 相关文献

参考文献6

  • 1Diener HC, Bogousslavsky J, Brass LM, et al. Aspirin and clopidogrel compared with clopidogrel alone after recent isehaemie stroke or transient ischaenric attack in high -risk patients (MATCH) : randomised, double - blind, placebo - controlled trial. Lancet 2004;364:331 -7.
  • 2脑卒中患者临床神经功能缺损程度评分标准(1995)[J].中华神经科杂志,1996,29(6):381-383. 被引量:15757
  • 3王拥军.氯吡格雷稳定易损斑块[J].国外医学(脑血管疾病分册),2005,13(10):734-736. 被引量:21
  • 4Caplan LR, Wityk RJ, Glass TA, et at. New England Medical Centerl : osterior circu- lation registry[ JJ. Annals of Neurology ,2004,56 ( 3 ) : 389 - 398.
  • 5辛勇通,黄艮彬,魏鼎泰,陆国云.后循环梗死CISS亚型分析[J].脑与神经疾病杂志,2013,21(5):321-323. 被引量:1
  • 6Wong KS, Chen C, Fu J, et al. Clopidogrel plus aspirin versus aspirin alone for re- ducing embolisation in patients with acute spmptomatic cerebral or carotid artery ste- nosis ( CLAIR study) : a randomised, open - label, blinded - endpoint tria [ J ]. Lan- cet Neurol,2010,95:489 -497.

二级参考文献20

  • 1周衡,王拥军,王素香,赵性泉.急性缺血性脑卒中的TOAST亚型分析[J].中华内科杂志,2004,43(7):495-498. 被引量:65
  • 2Rioufol G, Gilard M, Finet G, et al. Evolution of spontaneous atherosclerotic plaque rupture with medical therapy: long-term follow-up with intravascular ultrasound. Circulation, 2004, 110:2875 -2880.
  • 3DeGraba TJ. Immunogenetic susceptibility of atherosclerotic stroke: implications on current and future treatment of vascular inflammation.Stroke, 2004, 35:2712 -2719.
  • 4Geisler T, Bhatt DL. The role of inflammation in atherothrombosis: current and future strategies of medical treatment. Med Sci Monit, 2004,10:RA308 -RA316.
  • 5Tedgui A. The role of inflammation in atherothrombosis: implications for clinical practice. Vasc Med, 2005, 10:45 -53.
  • 6Chew DP, Bhatt DL, Robbins MA, et al. Effect of clopidogrel added to aspirin before percutaneous coronary intervention on the risk associated with C-reactive protein. Am J Cardiol, 2001,88:672 -674.
  • 7Hermann A, Rauch BH, Braun M, et al. Platelet CD40 ligand(CD40L)-subcellular localization, regulation of expression, and inhibition by clopidogrel. Platelets, 2001, 12:74 -82.
  • 8Jurk K, Kehrel BE. Platelets: physiology and biochemistry. Semin Thromb Hemost, 2005, 31: 381 - 392.
  • 9Markus HS, Droste DW, Kaps M, et al. Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial.Circulation, 2005, 111: 2233 - 2240.
  • 10Gao S, Wang Y J, Xu A D,et al. Chinese ischemic strokesubclassification. Front Neurol,2011,2:6.

共引文献15773

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部