复发动脉粥样硬化性脑梗死患者阿司匹林抵抗的相关因素分析

目的：探讨分析复发动脉粥样硬化性脑梗死患者阿司匹林抵抗的相关因素。方法：把2012年6月至2014年9月到我院实施诊治的86例复发动脉粥样硬化性脑梗死患者作为研究对象，收集患者临床资料，全部患者均服用过阿司匹林，服用时间≥1个月，基于血小板聚集率将86例患者分为A组（阿司匹林抵抗）、B组（阿司匹林半抵抗）以及C组（阿司匹林敏感），对比分析三组患者临床资料和各项检查指标。结果：通过对比分析，三组患者在腹围大小、体重指数以及年龄等方面比较无显著差异（P〉0.05）；A组和B组、C组相比较，男性患者、过量饮酒者、糖尿病以及高脂血症患者所占比重高，且患者入院时Ca2＋、CSS评分、FIB以及HCY均比其他两组高，组问数据比较差异明显（P〈005）；经多因素分析发现高脂血症以及糖尿病和复发动脉粥样硬化性脑梗死患者阿司匹林抵抗相关。结论：经本次研究结果的分析可知。高脂血症以及糖尿病可能是复发粥样动脉硬化性脑梗死患者阿司匹林抵抗的影响因素，要想改善患者阿司匹林抵抗症状，应及时调节和改善血糖、血脂。子在疾病临床治疗中，应根据患者自身实际制定相应的治疗方案，以保证治行效果。

Objective To analyze the correlation factors of aspirin resistance in patients with recurrent atherosclerotic cerebral infarction. Method： The June 2012 to September 2014 to our hospital implementation of the diagnosis and treatment of 86 cases of recurrence of atherosclerosis in cerebral infarction patients as the research object, collecting clinical data of the patients. All patients were treated with aspirin, taking time is more than or equal to 1 month, based on platelet aggregation rate will be 86 cases were divided into group A （ aspirin resistance ）, group B （aspirin semi resistance） and group C （aspirin sensitive）, comparative analysis of three groups of patients with clinical data and the check index. Result： Through the comparative analysis, three groups of patients in terms of size of girth, body mass index and age there is no significant difference （P 〉 0. 05）. Compared with group A and group B, group C, male patients, excessive drinking, diabetes and hyperlipidemia in patients with hyperlipidemia accounted for a high proportion, and patients admitted to the hospital when Ca2 ＋ , CSS, FIB and Hcy was higher than that of the other two groups of high, between group differences were obvious （ P 〈 0. 05） ; multivariate analysis found that high - fat hyper- lipidemia and diabetes and recurrence of atherosclerosis in cerebral infarction patients with aspirin resistance. Conclusion ： Through the analysis of the Results of this study shows, hy- perlipidemia anti diabetes may and influencing factors of recurrence of atheroselerosis cerebral infarction patients with aspirin resistance and to improvement of aspirin resistance in patients with symptoms, should be timely adjust and improve the blood glucose and blood lipid. In the clinical treatment of disease, the corresponding treatment plan should he made according to the actual conditions of the patients themselves, so as to ensure the treatment effect.