2型糖尿病患者血清HSP60浓度的变化及意义

目的：探讨2型糖尿病（T2DM）患者血清HSP60浓度的变化及意义。方法：选择75例门诊研究对象，根据葡萄糖耐量试验（OGTr）结果分为正常对照组35例，T2DM组40例。测定其血清HSW00、空腹血糖（FBG）、空腹胰岛素（FINs）、糖化血红蛋白（HbA1c）及血脂水平，计算胰岛素抵抗指数（HOMA-IR），并分析T2DM组HSP60与其余指标的相关性。结果：两组间体重指数（BMI）、腰／臀比（WHR）及血脂水平无明显差异（P〉0．05）。T2DM组FBG、FINs、HbA1c、HSP60及HOMA-IR水平明显高于对照组（P〈0．05），T2DM组HSP60与FINs及HOMA—IR呈正相关（P〈0．01）。结论：HSP60可能是一个与炎症反应相关，参与糖尿病发生发展的潜在因素。随着对HSP60及糖尿病发病机制的进一步研究，我们推测HSP60有可能成为预测2型糖尿病发生的一个新指标。

Objective： To understand the correlation between HSP60 concentration and patients with type 2 diabetes （T2DM）. Method ：According to oral glucose tolerance test （OGTI＇） ,75 participants were divided into a control group of 35 participants and 40 patients with type 2 diabetes. Serum HSP60 ,fasting blood glucose（ FBG）, fasting insulin（ FINs）, glycosylated hemoglobin （ HbA 1 c） and blood lipids were tested for each subject, and homeostasis model assessment of insulin resistance index （ HOMA - IR） was calculated, and analyzed the correlation in T2DM group between HSP60 and the remaining indicators. Result：BMI,WHR and blood lipids did not show significant differences in two groups（ P 〉 0. 05 ）. FBG, FINs,HbA1 c,serum HSP60 and HOMA -IR of T2DM group were significantly increased than control group（ P 〈0. 05 ）. Moreover, HSP60 was positively correlated with FINs and HO- MA - IR（P 〈 0. 01 ）. Conclusion：HSP60 might be a factor underlying involved in inflammation, and participate in the occurrence and development of diabetes. With further study of HSP60 and pathogenesis of diabetes,we hypothesized that HSP60 may become a new indicator to predict type 2 diabetes.