克罗米酚联合人绝经期促性腺激素治疗小卵泡排卵的效果分析

Analysis of Clomiphene Citrate Combined with Human Menopausal Gonadotropin Treatment of Small Follicle Ovulation Effect

目的:比较克罗米酚联合人绝经期促性腺激素(HMG)治疗小卵泡排卵的疗效。方法:将小卵泡排卵36例251个治疗周期,随机分成A、B两组,A组:单独使用HMG;B组:同时用克罗米芬和HMG。观察、比较两组的排卵率、妊娠率、早期流产率等。结果:B组最大卵泡略>A组,差异无统计学意义(P>0.05);A组每日卵泡MFD≥15mm卵泡个数<B组,差异有统计学意义(P<0.05)。2每日子宫内膜、宫颈情况比较:A、B两组子宫内膜平均厚度、宫颈Insler评分相当,差异均无统计学意义(P>0.05)。3治疗效果比较:妊娠率:A组妊娠率、未破裂卵泡黄素化综合征发生率、多胎率均<B组,差异均有统计学意义(P<0.05);早期流产率:A组>B组,差异有统计学意义(P<0.05)。结论:克罗米芬联合应用HMG可促进卵泡发育,提高妊娠率和降低早期流产率。

Objective： To compare the clomiphene citrate combined with human menopausal gonadotropin（HMG） effect in the treatment of small follicle ovulation. Methods：36 cases of small follicle ovulation 251 treatment cycles, were randomly divided into A, B two groups, group A： HMG alone; group B： at the same time with clomiphene citrate and HMG. Comparison of two groups of observation, the ovulation rate, pregnancy rate, abortion rate etc.. Results： In B group, the largest follicle slightly, A group, the difference was not statistically significant（P〉0.05）; group A MFD is more than or equal to 15 mm daily follicle follicle number was less than B group, the difference was statistically significant（P〈0.05）. The daily endometrial, cervical： A, B two groups of endometrial thickness, the cervical Insler score, the difference was not statistically significant（P〉0.05）. The comparison of the treatment effect： the pregnancy rate： A group, the pregnancy rate of luteinized unruptured follicle syndrome, the incidence of multiple pregnancy rate were lower than B group, the differences were statistically significant（P〈0.05）; early abortion rate： A group, B group, the difference was statistically significant（P〈0.05）. Conclusions：Clomiphene citrate combined with application of HMG could promote the follicular development, improve the pregnancy rate and decrease the rate of early spontaneous abortion.