摘要
通过提出理论最大安全用量,采用欧盟消费者安全委员会(SCCS)指导文件、Cons Expo软件及WHO每日耐受量(TDI)计算二噁烷的经皮、经呼吸及经口的暴露情况,对化妆品中的二噁烷进行了安全性评价。结果表明当二噁烷在不同类型的化妆品中的平均含量不超过37 mg/kg时,理论上不会对消费者造成显著的毒理风险。
By setting up theoretical maximum dosage, the risk of 1, 4-dioxane in cosmetics was evaluated based on the exposure level via dermal,inhalation and oral routes that calculated with TDI recommended by WHO when following SCCS guidelines and using Cons Expro Computer program. The result indicated that the dosage of 1, 4-dioxane in cosmetic products up to 37 mg/kg does not pose a significant health risk to the general public.
出处
《日用化学品科学》
CAS
2015年第7期8-10,19,共4页
Detergent & Cosmetics
关键词
化妆品
二噁烷
风险评估
理论最大安全用量
cosmetics
1
4-dioxane
risk assessment
theoretical maximum dosage
