摘要
目的：研究探讨ANA谱﹑抗心磷脂抗体﹑抗核抗体﹑抗ds-DNA水平与SLE活动性的关系。方法：选择2013年1月至2014年6月我院风湿免疫科住院的SLE患者共125例为SLE组，同时选择同期在我院进行体检的健康者共30例为健康组。观察SLE活动期、SLE非活动期与健康组抗心磷脂抗体、抗核抗体、抗ds-DNA阳性率情况，SLE活动期、SLE非活动期与健康组抗心磷脂抗体浓度情况。结果： SLE活动期的ACA- IgG（19.21±0.79） RU/ml、ACA- IgM（17.01±0.76）RU/ml水平均显著高于健康组和SLE非活动期，差异有统计学意义（P〈0.05）。健康组与SLE非活动期抗心磷脂抗体浓度相比，差异无统计学意义（P〉0.05）。结论：ANA谱、抗心磷脂抗体、抗核抗体、抗ds-DNA水平的测定，对于SLE活动期的患者能够有效检测出病情，进而较好的对复发进行预测，并且有利于指导治疗。
Objective：To investigate ANA spectrum anti-cardiolipin antibodies, antinuclear antibody anti-ds-DNA levels and the relationship between the activity of SLE.Methods：from January 2013 to June 2014 in our hospital Rheumatology SLE patients hospitalized for a total of 125 cases of SLE group, and select the corresponding period in our hospital for examination of a total of 30 cases of healthy people healthy group. Observed active SLE, SLE and healthy inactive group of anti-cardiolipin antibodies, antinuclear antibody, anti-ds-DNA positive rate case, SLE active, SLE and healthy inactive group anticardiolipin antibody concentrations.Results： Health group and inactive SLE anti-cardiolipin antibodies, antinuclear antibodies, anti-ds-DNA positive rate, the difference was not statistically significant （P〉 0.05）. ACA- IgG SLE activity period （19.21 ± 0.79） RU / ml, ACA- IgM （17.01 ± 0.76） RU / ml were significantly higher than the healthy group and inactive SLE, the difference was statistically significant （P 〈0.05）. Health group compared with inactive SLE anticardiolipin antibody concentration, the difference was not statistically significant （P〉 0.05）. Anti-U1-nRNP antibody of active SLE, anti-Sm antibodies.Conclusions：ANA spectrum, anti-cardiolipin antibodies, antinuclear antibodies, anti-ds-DNA levels measured for patients with active SLE can effectively detect the disease, and thus a better prediction of relapse, and help guide treatment.
出处
《医学检验与临床》
2015年第3期22-23,15,共3页
Medical Laboratory Science and Clinics
