血清胱抑素C、β2-微球蛋白、尿微量白蛋白/尿肌酐比值在高血压病患者早期肾损害诊断中的价值分析

Value analysis of serum cystatin C, β2-microglobulin, urinary albumin / creatinine ratio in early diagnosis of hypertensive patients with renal damage

探讨血清胱抑素C（CysC）、β2-微球蛋白（β2-MG）、尿微量白蛋白/尿肌酐比值（UA/Cr）在高血压病患者早期肾损害诊断中的价值。方法：选取2013年1月至2014年6月间我院收治的289例高血压患者作为研究对象，并选取同期90例健康体检者作为对照组。检测两组的CysC、β2-MG、UA、Cr水平。结果：高血压患者CysC、β2-MG、UA／Cr水平显著高于对照组（P〈0．05），且高血压患者CysC、β2-MG、UA、Cr水平随血压的升高明显增大（P〈0．05）。CysC检测阳性率为64．4％，β2-MG检测阳性率为53．3％，UA／Cr检测阳性率为52．2％。结论：CysC、β2-MG、UA／Cr可作为高血压患者早期肾损伤的诊断指标。

Objective ： To investigate the value of serum cystatin C, β2-microglobulin, urinary albumin / creatinine ratio in early r diagnosis of hypertensive patients with enal damage. Methods ： 289 cases of hypertensive patients from January 2013 to June 2014 in our hospital were selected as research subjects, and 90 cases of healthy subjects in the same period were selected as control subjects. The CysC, β2-MG, UA, Cr levels of two groups were detected.Results ： The CysC, β2-MG, UA /Cr levels of hypertension patients were significantly higher than control group （P〈0.05）, and the CysC, β2-MG, UA /Cr levels of hypertension patients were significantly increased with increasing of blood pressure （P〈0.05）. The diagnosis positive rate of CysC was 64.4%, diagnosis positive rate of β2-MG d was 53.3%, diagnosis positive rate of UA/Cr was 52.2%. Conclusions ： CysC, β2-MG, UA/Cr can be used as diagnostic marker of renal damage of hypertension patients.