活血化瘀方对肝肾阴虚·瘀血阻络型肝病血液流变学的影响

Promoting blood circulation to remove blood stasis in treatment of liver disease from blood rheology

目的从血液流变学角度探讨活血化瘀方在肝病治疗中的应用。方法对160例患者资料进行回顾性分析。其中肝肾阴虚型78例,瘀血阻络型82例。研究组肝肾阴虚型39例,瘀血阻络型41例,对照组肝肾阴虚型39例,瘀血阻络型41例。对照组临床上服用拉夫米定药物治疗,研究组在对照组治疗的基础上联合活血化瘀方进行治疗。比较2组患者的红细胞聚集指数、血浆黏度、红细胞压积、全血高切黏度、全血低切黏度、红细胞膜SOD活力、红细胞膜MDA含量7个指标。结果肝肾阴虚型研究组的全血低切黏度、红细胞指数和红细胞膜MDA含量与对照组比较差异有统计学意义(P<0.05);瘀血阻络型研究组的全血低切黏度、血浆黏度、红细胞聚集指数和红细胞膜MDA含量与对照组比较差异有统计学意义(P<0.05)。结论活血化瘀药能够改善血液循环、血管通透性,保护肝细胞,促进炎症病灶的消退、软化和吸收增生性病灶,改善机体免疫功能。

Objective Application of promoting blood circulation to remove blood stasis in the treatment of liver disease from the blood rheology .Methods For 160 patients were retrospectively analyzed ,including 78 cases of ganshenyinxu type ,yux-uezuluo type 82 cases ,the study group （ganshenyinxu type 39 cases ,41 cases of yuxuezuluo type ） and control group （gan-shenyinxu type 39 cases ,41 cases of yuxuezuluo type） .The control group patients taking lamivudine drug ,the experimental group based on the control group treatment combined with promoting blood circulation and removing blood stasis drugs .Com-paring the two groups of patients with red cell aggregation index ,plasma viscosity ,hematocrit ,whole blood viscosity ,whole blood low shear viscosity ,Erythrocyte SOD activity ,erythrocyte MDA content of seven indicators .Results Yin deficiency of liver and kidney experimentl group had statistical significance （ P〈0 .05 ）;between experimental group and control group differences in some index （ P〈0 .05 ） .Conclusion Promoting blood circulation to remove blood stasis can effectively im-prove the clinical symptoms of patients ,is worthy of extensive application in clinic .